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Following an open splenectomy, a crucial aspect of patient care involves the prevention of infection due to the loss of splenic function. The spleen plays an essential role in filtering bacteria from the blood and contributing to the immune response. Patients who have undergone this procedure are at an increased risk for infections, particularly from encapsulated organisms like Streptococcus pneumoniae.

One of the most vital instructions for patients post-splenectomy is to follow up with their primary care provider to receive appropriate vaccinations. These vaccinations typically include those against pneumococcus, meningococcus, and Haemophilus influenzae type b, which are particularly important for enhancing the patient's immune protection after the spleen's removal. Ensuring that the patient receives these vaccinations helps reduce the risk of severe infections, making it a paramount recommendation.

While continuing antibiotics, avoiding international travel, and lifting restrictions may be considerations, the emphasis on vaccination underscores the need for ongoing preventative health measures specific to the patient's altered immune status after splenectomy.